| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R<1> and R<2> are lower alkyl; R<3> is imidazolyl shown by the formula II or formula III (R<4> is H, or lower alkyl); Y is OH, lower alkoxy, amino, etc.] and its salt. EXAMPLE:N<alpha>-[(S)-3,3-Dimethyl-4-oxo-2-acetidinylcarbonyl]--L- histidyl-L-prolin amide. USE:An improver for disturbance of consciousness in schizophrenia, depression, etc., an improver for hypobulia, dejection, etc. PREPARATION:For example, a compound shown by the formula (V and a compound shown by the formula V as starting raw materials are reacted, the prepared intermediate and a compound shown by the formula VI are subjected to peptide synthesis reaction preferably by azide method. |
