| 摘要 |
<p>Sorbinil is obtained in novel manner by optical resolution of racemic 2,3-dihydrospiro-6-fluoro¢4H-l-benzopyran-4,4'-imidazolidine!-2',5'-dione either (a) by direct resolution via the (-)-3-aminomethylpinane salt of sorbinil or (b) by a double resolving agent technique via a mother liquor concentrate of either the (+)-3-amino-methylpinane or the (-)-2-amino-2-norpinane salt of sorbinil, followed by the quinine salt of sorbinil. The novel process gives good yields of sorbinil with lower solvent volumes and without the use of a highly toxic resolving agent. Sorbinil has the following formula: < IMG > (I)</p> |
