| 摘要 |
PCT No. PCT/GB85/00325 Sec. 371 Date Mar. 18, 1986 Sec. 102(e) Date Mar. 18, 1986 PCT Filed Jul. 22, 1985 PCT Pub. No. WO86/00926 PCT Pub. Date Feb. 13, 1986.A eukaryotic expression vector includes a controllable repressor operator sequence witin the expression control sequence of the vector. The controllable repressor operator sequence represses expression of a heterologous structural gene located downstream of the expression control sequence in the presence of a gene product or a combination of gene products of a yeast mating type locus. This allows control of the expression level of the heterologous structural gene. Controllable repressor operator sequences responsive to the a1/ alpha 2 and alpha 2 gene products of the MATa and MAT alpha yeast mating type locus alleles are described, both derived from genetic material and synthesized chemically. |
