发明名称 |
SPERGUALIN-RELATED COMPOUNDS HAVING A PHENYLENE GROUP,A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
摘要 |
The present invention reales to novel Spergualin related compounds, and a process for producing the same. More particularly, the invention reales to Spergualin related compounds of the formula: …<CHEM>… wherein R1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen alom; m and n are each 0 or an integer of 1 to 5, and salts thereof, as well as a process for producing the compounds of formula (I) and salts thereof by removing the protecting groups from a protected Spergualin related compounds of the formula: …<CHEM>… wherein R1 is a straight chain or branched lower alkylene group which may be substituted by a hydroxymethyl group, the hydroxyl group of which may be protected; R2 is an amino protecting group; R3 is a protected amino group; X, m and n are as defined above. …<??>The compounds of the formula I have anti-tumor activity and can therefore be used as medicaments. |
申请公布号 |
ZA8501567(B) |
申请公布日期 |
1986.01.29 |
申请号 |
ZA19850001567 |
申请日期 |
1985.03.01 |
申请人 |
MICROBIAL CHEMISTRY RESEARCH FOUNDATION |
发明人 |
HAMAO UMEZAWA;RINZO HISHISAWA;TERUYA NAKAMURA;TOMIO TAKEUCHI;KATSUTOSHI TAKAHASHI;YOSHIHISA UMEDA |
分类号 |
A61K31/165;A61P31/04;A61P35/00;C07C67/00;C07C239/00;C07C277/08;C07C279/14;C07C279/18;C07D209/48 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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