REKOMBINANTFAKTOR VIII-R.

摘要

Human Factor VIII-R essentially free of other proteins of human origin is disclosed. Characteristically, the Factor VIII-R protein is glycosylated. The Factor VIII-R is produced by recombinant DNA techniques in host cells or other self-replicating systems and is provided in essentially pure form. Also provided are methods and compositions for preparing the above-described Factor VIII-R as well as therapeutic compositions and uses for the Factor VIII-R protein in the treatment of coagulation disorders in humans and animals. The invention further provides replicable expression vectors incorporated with a DNA sequence encoding human Factor VIII-R and host cell or cell-free self-replicating systems transformed or transfected thereby.