Garosaminic cpd. - for medical use as antibiotic

摘要

The garosaminic cpd. 1-N-ethyl sisomycin, of formula (I) is prepared by (a) reacting the sisomycin of formula (II) with 3,4-dihydro 2H-pyrane of formula (III) to obtain 3,2'',4''-tri-O-tetrahydropyranyl sisomycin; (b) reacting the prod. with ethyl iodide in presence of sodium hydride to obtain 1-N-ethyl 3,2'',4''-tri-O-tetrahydro pyranyl sisomycin; and (c) hydrolysing this in dil. mineral acid.