ANTICUERPO MONOCLONAL ANTI-RECEPTOR A DE INTERLEUCINA 17 (IL-17RA) O FRAGMENTO DE UNION A ANTIGENO DEL MISMO; POLINUCLEOTIDO QUE LO CODIFICA; METODO DE PREPARACION; Y METODO PARA TRATAR UN TRASTORNO INFLUIDO POR LA ACTIVACION DE IL-17RA.

摘要

The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.