USE OF 5,6,7,8-TETRAHYDROQUINOLINES AND 5,6-DIHYDROPYRIDINESAS LEUKOTRIENE AND LIPXYGENASE INHIBITOR AND THEIR NOVEL 3-SUBSTITUTED COMPOUNDS

摘要

Compounds (many of which are novel) of the formula …… wherein D is N or N-O;… n is zero or 1;… R1 is H, C1-4 alkyl, cyclopropyl or phenyl optionally substituted by one or two substituents independently selected from halogen, CF3, SCH3, phenyl, OCH3, OH, NO2, NR3R4(R3 is H, C1-4 alkyl, acyl or aroyl and R4 is H or C1-4 alkyl), 1-pyrrolidinyl, 1-piperidinyl, OCOCH3, (OCOC6H5 and OSi-(CH3)2C(CH3)3;… R2 is H, C1-4 alkyl, COOR5 (R5 is H or C1-4 alkyl or a pharmaceutically-acceptable cation), CH2OH, CHO, CH=CH-(CH2)d-R6 (d is 0, 1, 2 or 3 and R6 is CH2OH, CH2Cl or COOR5 in which R5 is as defined above) or CH2CH2(CH2)dR6 (d and R6 are as defined above); and …… in which X<1> is optionally substituted phenyl as defined above, 2-furyl or 2-thienyl, X<2> is optionally substituted phenyl as defined above, CO(CH2)3R7, CHOH(CH2)R7 (R7 is H, OH, Cl or 2-morpholinyloxy), 2-furanyl, 2,3-dihydro-2-furyl, 2,3-dihydro-5-furyl or 2-furyl) and X<3> is optionally substituted phenyl as defined above;… and pharmaceutically-acceptable salts thereof. …These compounds can have utility in therapy, e.g. for the curative or prophylactic treatment of allergy, asthma, chronic bronchitis, cystic fibrosis, psoriasis or inflammatory bowel diseases.