| 摘要 |
<p>Compounds of the formula (I): <IMAGE> (I) and pharmaceutically acceptable acid addition salts thereof, wherein, Ar is optionally substituted phenyl or naphthyl, or pyridyl; E is O, S or a bond; R5 is hydrogen, and J is C3-5 polymethylene, optionally substituted by one or two groups selected from methyl or optionally derivatized hydroxy; or Ar and R5 together form a group <IMAGE> where Ar1 is optionally substituted 1,2-phenylene; Z is O or CH2, and m is 0 or 1, when E is O or S, or 1 when E is bond; R1 is hydrogen, C1-4 alkyl optionally substituted phenyl; C3-8 alkanoyl, or phenyl C2-8 alkanoyl, any phenyl moiety being optionally substituted; a group COR2 where R2 is C2-3 alkoxy, phenyl C1-4 alkoxy, the phenyl moiety being optionally substituted, or C1-4 alkoxy C3-4 alkoxy; or a group CXNHR3 where X is O or S and R3 is C2-4 alkyl, C2-4 alkenyl, phenyl or phenyl C1-4 alkyl, any phenyl moiety being optionally substituted; and R4 is hydrogen or C1-4 alkyl, compositions containing them, and processes for their preparation.</p> |
