发明名称 Methods of alleviating convulsions and pain employing 4-aryloxy-1,2,3,4 tetrahydroisoquinolines
摘要 This invention relates to 4-aryloxy-1,2,3,4-tetrahydroisoquinolines of the formula <IMAGE> where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl alkoxy and nitro; R is hydrogen and alkyl; R1 is hydrogen, alkyl, aralkyl, <IMAGE> and CO2R4 where R1 is aryl and alkyl; R2 and R3 are the same or differnt and are hydrogen and alkyl or R2 and R3 are fused together to form a pyrrolidino or a piperidino ring substituent; and m is an integer of 1 or 2; n is an integer of 2 or 3; and a pharmaceutically acceptable acid addition salt thereof.
申请公布号 US4551474(A) 申请公布日期 1985.11.05
申请号 US19840639057 申请日期 1984.08.09
申请人 HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED 发明人 EFFLAND, RICHARD C.;DAVIS, LARRY;KLEIN, JOSEPH T.
分类号 C07D217/24;(IPC1-7):A61K31/47;C07D401/06 主分类号 C07D217/24
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