| 摘要 |
NEW MATERIAL:A compound of formula I [R1, R2 are H, halogen, hydroxy; R3, R4 are H, lower alkyl which may be substituted, cycloalkyl; X is H, lower alkyl and aryl which may be substituted; Y is >C=O, >CH-OR5 (R5 is H, acyl); m is 0-2; n is 1-6] and its salt. EXAMPLE:Methyl 7-methoxy-3-oxo-4-[ 3-( 4-phenylpiperazin-1-yl )propyl ]-3,4-dihydro-2H-1,5-benzoxathiepin-4-carboxylate. USE:Preventive and remedy for isthemic cardiopathies such as angina pectoris, or myocardial infarction and disorders in cerebral circulation such as thrombosis hypertension and cerebrovascular twitch. PREPARATION:The condensation reaction between a compound of formula IIand another compound of formula III (W is halogen) is followed by reduction reaction of the produce to give the compound of formula I . |
