| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is (protected)amino; R<2> is (substituted)aryl, (substituted)heterocyclic group, cyano, H, or tri(lower)alkylsilyl; R<3> is (protected)carboxy; A is -CH=CH- or -CidenticalC-] or its salt. EXAMPLE:7-[2-( 2-Aminothiazol-4-yl )-2-allyloxyiminoacetamido]-3-[(Z)-2-(3-pyridyl) vinylthiomethyl]-3-cephem-4-carboxylic acid (synisomer). USE:Antibacterial agent. PREPARATION:The compound of formula I can be produced, e.g. by acylating the 7-amino-3-cephem-4-carboxylic acid compound of formula II or its reactive derivative at the amino group or its salt, with an acylating agent.
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