发明名称 |
OPTICALLY-ACTIVE DIAMIDE DERIVATIVES |
摘要 |
<p>A novel optically active diamide derivative represented by the following general formula is provided, which is useful as a starting material for asymmetric synthesis of optically active compounds, < IMG > wherein: R1 is an acyclic or cyclic, divalent atomic group containing at least one carbon atom which will, upon substitution of one of the heterocyclic groups in the formula with a nucleophilic reagent, stand as an asymmetric center in the substitution product; R2 is a substituent which has such a configuration and a molecular size that the regioselectivity in the substitution reaction of the heterocyclic group with the nucleophilic reagent can be determined by a stereochemical interaction thereof with the substituent R1, the steric configuration of the two asymmetric carbon atoms to which the R2 substituents are attached being identical; X is a sulfur atom or an oxygen atom; and n is an integer which is 1 or 2. Such a diamide derivative can be prepared by subjecting the corresponding dicarboxylic acid or an anhydride thereof with the corresponding heterocyclic compound to condensation reaction in the presence of a condensation agent. The optically-active diamide derivative can be used in the reaction with a nucleophilic reagent to obtain an optically-active compound. The resulting compound can be further modified by subjecting it to reaction with other nucleophilic reagent or to hydrolysis.</p> |
申请公布号 |
CA1184178(A) |
申请公布日期 |
1985.03.19 |
申请号 |
CA19820417462 |
申请日期 |
1982.12.10 |
申请人 |
YAMASA SHOYU KABUSHIKI KAISHA |
发明人 |
FUJITA, EIICHI;NAGAO, YOSHIMITSU;IKEDA, TAKAO;INOUE, TAKEHISA |
分类号 |
C07D295/18;C07B31/00;C07B53/00;C07B61/00;C07C67/00;C07D263/16;C07D265/08;C07D277/16;C07D279/06;C07D283/02;C07D295/185;(IPC1-7):C07D277/16;C07D417/06 |
主分类号 |
C07D295/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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