| 摘要 |
Compounds the structural formula <IMAGE> or their pharmaceutically acceptable salts, wherein X is H or CH3, Z is NH2 or OR6, R1 is a C1-8 alkyl, C3-6-cycloalkylmethyl, or phenyl-C1-2alkyl group, R2 is hydrogen, hydroxy, chloro or fluoro, R3 is hydrogen, hydroxy, methoxy, -OCO-(C1-6-alkyl) or morpholinoethoxy, R4 and R5 may be the same or different and are H or C1-6alkyl, R6 is H, C1-4 alkyl, C3-5 alkenyl, C3-7 cycloalkyl phenyl, or phenyl substituted by one to three alkyl groups with a total of 4 carbon atoms are useful opiod antagonists.
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