发明名称 |
Amino acid isomers, their production and their medicinal use |
摘要 |
The (-)-D-isomers of compounds of the general formula <IMAGE> (I) in which X stands for an acidic radical, especially a radical of phosphonic acid, sulphonic acid, boronic acid or tetrazole, R stands for an alkylene, alkenylene or alkynylene radical with 3 or more carbon atoms, preferably 3 to 6 carbon atoms, or a C3 to C7 cycloalkyl radical, and A and B independently of each other stand for a hydrogen atom or a lipophilic radical, especially an ester radical, or salts thereof, or pharmaceutically acceptable bioprecursors thereof, especially (-)-D-aminophosphonopentanoic acid and (-)-D-aminophosphonoheptanoic acid, find use in the treatment of diseases of the central nervous system. The compound aminophosphonoheptanoic acid is also novel as a racemic mixture and the present invention also relates to that compound in racemic form which may be used in the same way as the said (-)-D-isomers.
|
申请公布号 |
US4483853(A) |
申请公布日期 |
1984.11.20 |
申请号 |
US19820434361 |
申请日期 |
1982.10.14 |
申请人 |
COLLINS, JAMES F.;CURRY, KENNETH;SCHWARCZ, ROBERT |
发明人 |
COLLINS, JAMES F.;CURRY, KENNETH;SCHWARCZ, ROBERT |
分类号 |
C07F5/02;A61K31/195;A61K31/22;A61K31/41;A61P25/00;A61P25/08;C07C67/00;C07C301/00;C07C303/16;C07C309/18;C07D257/04;C07F9/09;C07F9/38;C07F9/40;(IPC1-7):A61K31/66;A61K31/16;A61K31/19 |
主分类号 |
C07F5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|