PROCESS FOR PREPARING SULFONYLUREAS

摘要

Sulfonylureas of formula (I) and their salts were newly prepd. by reacting benzene sulfinic acids of formula (II) or their alkali metal salts with N-R1-N'-hydroxyureas in the presence of benzene sulfinic acid halide or an acidic condensing agent. In the formulas X is C3-6 alkylene or alkenylene; Y is C2-3 alkylene; and R1 is C4-6 alkyl, cycloalkyl, alkylcycloalkyl, dialkylcycloalkyl, cycloalkylalkyl, C4-9 cycloalkenyl, methyl cyclopentylmethyl, cyclohexenyl methyl, etc. The prods. are used in the treatment of diabetes mellitus by lowering blood sugar levels.