Oligonucleotide derivatives and production thereof.

摘要

Biotin- or 2,4-dinitrophenyl-oligodeoxyribo-nucleotide derivative represented by the formula shown below and its preparation method is disclosed:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="18" wi="64" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="31" wi="80" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>m and n are each 0 or a natural number; R<Sup>1</Sup> is a straight or branched hydrocarbon residue; and B is a base constituting the nucleotide (in which when a plural number of B exist, they may be either identical or different). This compound is useful for use as a non-radioactive affinity probe for nucleic acid or a primer.