BUKSPOTTSKOERTELNS GRF HOS MAENNISKAN.

摘要

The invention relates to the synthesis of two surprisingly active fragments of human pancreatic GRF (growth hormone releasing factor) and an analogue which exhibits good biological activity. The synthetic peptides are extremely potent in stimulating the release of pituitary growth hormone in humans and in nonhuman animals and have the general formula: H-Tyr-Ala-Asp-Ala- Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-R15-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly- Glu-Ser-Asn-Gln-Glu-Arg-Gly-R40-Y wherein R15 is Gly or D- Ala, R40 is Ala or des-R40 and Y signifies the carboxyl moiety of the amino acid residue at the C-terminal and is the group -COOR1, -CR1O, -CONHNHR1,-CON(R1) (R2) or -CH2OR1, wherein R1 and R2 are lower alkyl or hydrogen. The two aforementioned fragments contain the 29 or the 32 N-terminal residue and each is amidated at the C- terminus. These peptides, as well as nontoxic salts thereof, may be administered therapeutically to animals, including humans.