| 摘要 |
<p>A method for increasing the production of a secondary metabolite, such as an antibiotic, in a fermentation which comprises periodically adding to the culture medium during the idiophase of the fermentation those nutrients essential for production of the desired secondary metabolite. Periodic addition of nutrients during the idiophase of a tylosin fermentation is shown to result in greater tylosin production in a given time than is obtained with conventional batch fermentation or a fermentation in which the nutrients are fed continuously to the fermentation during the idiophase. </p> |
