NOVEL PROCESS FOR PREPARING N-CYANO-N-METHYL-N(2-((METHYL-5-IMIDAZOLYL)METHYLTHIO)ETHYL

摘要

Cimetidine (VII) was prepd. by treating 4-methyl-5-hydroxymethyl imidazol-HCl with 2-aminoethanthiol-H2SO4 to give 86.2% 4-methy1-5[(2-aminoethyl) thiomethy1 imidazole, which was treated with NCN:C(OEt)SMe to give 78.3% N-cyano-N'=[2-((4-methyl-5 -imidazolyl) methylthio)ethyl -o-ethyl-isourea. Aminolysis of the latter compd. with MeNH2 gave 80.3% cimetidine.