| 摘要 |
<p>This invention relates to a method of stabilizing Interferon beta (Human Fibroblast Interferon (HFIF)), wherein a highly purified Interferon beta solution, admixed with known excipients therefor, is dialysed against an acetate buffer at pH 3.5 for about 48 hours. The resulting Interferon beta solution is admixed with from 0.5% to 10% wt/volume of polyvinyl pyrrolidone prior to or following filtration through a sterile filter, dispensed into glass vials, lyophilized, and the vials are sealed in vacuo and stored at 4 DEG C. </p> |
