| 摘要 |
Disclosed herein are the peptides possibly radio-labelled and having primary structures represented by the general formula (I): X-Ser-Gln-Gly-Gly-Ser-Asn-Y (I) wherein (1) X is H-Tyr-Gln-Ala-Lys and Y is a hydroxyl group, (2) X is pGlu-Ala-Lys(N epsilon -Tyr-H) and Y is a hydroxyl group, or (3) X is pGlu-Ala-Lys and Y is Tyr-OH. These peptides can be synthesized by bonding a pre-determined amino acid or a peptide to the nitrogen at one of the two ends of the starting material, H-Asn-OH or H-Asn-Tyr-OH, while leaving the carboxyl group at the other end thereof in a free state, and by successively repeating the same procedure on the thus prepared peptides. The symbols, Ser, Gln, Gly, Asn, Tyr, Ala and Lys used herein represent respectively a divalent residue formed by removing one hydrogen atom from the amino group of and further removing one hydroxyl group from the carboxyl group of the respective alpha- amino acids, serine, glutamine, glycine, asparagine, tyrosine, alanine and lysine. For instance, Ser represents the divalent residue, -NH-CH(CH2OH)-CO-. The symbol, pGlu, represents a monovalent residue formed by removing one hydroxyl group from the carboxyl group of pyroglutamic acid.
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