| 摘要 |
NEW MATERIAL:A compound shown by the formula[R1 is H, alkyl, acryl, R1-A- (A is neutral amino acid residue), etc.; R2 is OH, alkoxy, aryloxy, etc. R3 is H, acryl, alkyl, etc.; R4 is H, tosyl, trityl, etc.; R5 is H, alkyl, acyl, alkoxycarbonyl, etc.) and its salt. EXAMPLE:Gly-Ser-His-Lys.2(p-toluenesulfonic acid). USE:An antiulcer. Useful for remedying ulcer of digestive organ system such as gastric ulcer, duodenal ulcer, etc., after-stomatitis, burn, useful as antistress agent, sedative, analgesic, agent against aging for vasculature such as arteriosclerosis, etc. and organism. PROCESS:Peptide bonds are formed and protecting groups used properly are removed according to peptide synthesis (e.g., liquid phase method, solid phase method), by condensation method such as azide method, active esterification method, mixed acid anhydride method, etc. |
