| 摘要 |
salts of formula are(I) are new. (where X(-) is an anion; R is 1-7C opt. branched alkyla (opt. substd. by hydroxy, carboxy, alkoxycarbonyl, cyano, dialkylamnino, alkylcarbonyl, benzoyl (where the peny phenyl ring is otpt. substd. by one or more halo, alkyl )(opt. halo substd.) alkoxy, hydroxy, amino, mono- or dialkylamino, cyano or nitro gps.) thenoyl (the thienyl ring is opt. substd. by one or more halo, alkyl, cyano, or nitro gps)., pyridylcarbonyl, carbamoyl, dialkylcarbamoyl (where the two alkyl gps. together with the N atom may form a 5-6 membered heterocyclic opt. contg. a further O, S or N (substd. by alkyl or alkylcarbonyl) atom) or pyridyl) or R is dialkylcarbamoyl (where the two alkyl gps. together with the N atom may form a 5 or 6 membered heterocyclic opt. contg. a further O, S or N (substd. by alkyl or alkylcarbonyl) heteroatom), 2-4C alkenyl, 2-4C alkynyl, alkoxycarbonyl, 2-oxo-3-tetrahydrofuryl or 2-oxo-3-tetrahydropyranyl. R1 and R2 independently are phenyl, 3-7C cycloalkyl, alkyl or phenylalkylpephenalkyl or together with the N atom form a 5-7 membered heterocyclic, opt. contg. a further O, S or alkyl-substd.-N heteroatom ot R1 is phenyl (opt. substd. by one or more halo, alkyl (opt. substd. by one or more halo gps), alkoxy, hydroxy, amino, mono- or dialkylamino, cyano or nitro), 3-7C cycloalkyl, alkyl or phenalkyl and R2 is H including the corresponding bases when R2 is H). Anti-ulcer cyto-protecting cpds. In tests against ethanol induced ulcers is rats (A Roberts technique), (I) are orally active at doses of 1-100 mg/kg. |
