PRODUCTION OF 2BETA-SUBSTITUTED METHYLPENICILLIN DERIVATIVE

摘要

PURPOSE:To simply obtain the titled compound useful as a synthetic intermediate for beta-lactam antibiotic and beta-lactamase inhibitor, by subjecting azetidinone disulfide derivative and a specific compound to electrolytic reaction. CONSTITUTION:An azetidinone disulfide derivative {e.g. 3-methyl-2-[2- oxo-4-(benzothiazol-2-yl)dithioazetidin-1-yl]-3-butenoic acid p-nitrobenzyl ester, etc.} shown by formula I (R is nitrogen-containing heterocyclic group; R1 and R2 are H, halogen or acylamino; R3 is nitrogen-containing heterocyclic group) and a compound (salt) shown by the formula HY (Y is azido or selenocyanato) are subjected to electrolytic reaction to give the aimed compound shown by formula II.