| 摘要 |
There is described a collection of monoclonal antibodies the members of which being directed against human leucocyte interferon (HLI) which is natural or obtained by recombinant DNA technology. The monoclonal antibodies are preferably secreted by different hybridomas. It has been shown that individual monoclonal antibodies are not mutually inhibiting, i.e. bind together to HLI while others are mutually inhibiting, i.e. do not bind together to HLI. It has been shown furthermore that the collection consists of groups of antibodies, members of which recognize different epitopes (antigenic determinants) for HLI. Each a member of the different groups of antibodies can be used for a solid phase- sandwich test for HLI. In addition an antibody of the collection can be used for the purification of HLI by affinity chromatography. |
