4-Halo-1,8-naphthyridine derivatives useful as intermediates and processes for their preparation.

摘要

Compounds of formula <CHEM> in which R<1> is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 6 carbon atoms, alken (3,4,5 or 6)-yl of 3 to 6 carbon atoms or alkyn (3,4,5 or 6)-yl of 3 to 6 carbon atoms; R<2> is -CCl3, -CN, CO2H, -CO2R<7> where R<7> is alkyl of 1 to 6 carbon atoms or <CHEM> where R<8> and R<9> are independently hydrogen or alkyl of 1 to 6 carbon atoms, R<5> and R<6> are independently hydrogen; alkyl of 1 to 4 carbon atoms, halo, alkylamino of 1 to 4 carbon atoms, or alkoxy of 1 to 6 carbon atoms, or a salt thereof are disclosed which are useful as intermediates to compounds having gastric anti-secretory, and in some case diuretic, activity. Also described are processes for preparing the compounds.