| 摘要 |
NEW MATERIAL:A heat denaturing deoxyribonucleic acid MD-011. Elementary analysis %: C, 25.57-29.75; H, 3.80-4.75; N, 12.67-13.47; P, 7.30-7.91; Na, 8.12-11.59. Molecular weight: 30,000-1,000,000. Soluble in water and insoluble in ethanol, ether, acetone, etc. Negative to the orcinol, ninhydrin and anthrone reactions, and positive to the diphenylamine reaction. pH of the aqueous solution: 6.5-7.5. While powder. Base composition %: Guanine, 30.4; adenine, 16.9; cytosine, 30.8; thymine, 21.9. Loses the antitumor activity with deoxyribonuclease I, and no change with ribonuclease T2. Melting point and transition temperature: Indefinite. USE:An antitumor agent. PROCESS:A bacterium, e.g. bovine tubercle bacillus (ATCC19015), of the genus Mycobacterium is crushed and centrifuged to give an extract. A nucleic acid fraction of the resultant extract is then heat-treated. |
