| 摘要 |
The new compounds of the formula
<CHEM>
where
R1 and R2 independently are
<CHEM>
with the proviso at least one of R1 and R2 must be
<CHEM>
Y1 is F, Cl N(CH3)2 or C1-C4 alkoxy;
Y2 is H, F, Cl;
R3 is H,
<CHEM>
2-tetrahydropyranyl, 2-tetrahydrofuranyl,
<CHEM>
R6 is C1-C3 alkyl, benzyl, -CH2CH2OCH3 or
<CHEM>
R7 is C1-C4 alkyl or benzyl; and Ar is
<CHEM>
where
Y3 is H, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy or nitro;
e.g. 4,5-bis(4-fluorophenyl)-2-nitroimidazole; or their pharmaceutical suitable salts have antiinflammatory activity. A method for preparation of these compounds, involving nitration of 4,5-disubstituted-1-(substituted) imidazoles in 2-position, is given. |
