发明名称 CARBOXAMIDE VINYLOGUES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
摘要 Compounds of the formula <IMAGE> wherein Ar is phenyl; mono- or di-substituted phenyl, where the substituents are one to two halogens, one to two alkyls of 1 to 3 carbon atoms, or one amino, nitro, cyano or trifluoromethyl; or pyridinyl; R is hydrogen, chlorine, methyl or methoxy; R1 is hydrogen or methyl; R2 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, methyl-(cycloalkyl of 3 to 8 carbon atoms) or -A-R4, where A is alkylene of 2 to 3 carbon atoms, and R4 is hydroxyl, methylamino, dimethylamino, N-methyl-ethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-methyl-1-piperazinyl; or R1 and R2, together with each other and the nitrogen atom to which they are attached, form a 4- to 7-membered, saturated or mono-unsaturated, unsubstituted or substituted heterocycle which may contain nitrogen, oxygen, sulfur, sulfinyl or sulfonyl as additional ring members, where the substituents are alkyls of 1 to 3 carbon atoms. The compounds are useful as anticonvulsants.
申请公布号 ZA8004643(B) 申请公布日期 1982.04.28
申请号 ZA19800004643 申请日期 1980.07.31
申请人 THOMAE K GMBH 发明人 ENGEL W;TRUMMLITZ G;SEEGER E;KAEHLING J
分类号 A61K31/38;A61K31/381;A61K31/44;A61K31/4433;A61K31/445;A61K31/495;A61K31/535;A61P25/08;C07D333/62;C07D333/64;C07D409/06 主分类号 A61K31/38
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