| 摘要 |
Novel fluorinated diaminobutane derivatives are inhibitors of gamma-aminobutyric acid transaminase and have the following general Formula I:- <CHEM> wherein:- R1 represents hydrogen, C1-C6 alkyl or phenyl-C1-C4 alkyl; R2 represents hydrogen, C1-C6 alkyl, phenyl-C1-C4 alkyl, or R4 is as defined below; R3 represents hydrogen or, except when R2 represents R4, R4, where R4 is as defined below; each R4 independently represents C2-C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1-C4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; and p represents 1 or 2, and pharmaceutically acceptable acid addition salts thereof. |
