摘要 |
This invention provides novel interphenylene 9-this-11-oxo-12-azaprostanoic acid compounds and salts and other derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of bilogical activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives. They are therefore made into pharmaceutical compositions. …<??>The compounds have the formula: …<CHEM>… where R is caboxy or a carboxy ester or amide. A is a monocyclic ring, n is 3 or 4; m is 0, 1 or 2; R<1> is hydrogen, deuterium, or methyl, Z ic a C2-3 chain, R<2> is hydrogen or alkanoyl, R<3> is hydrogen or alkyl and R<4> is an optionally substituted aliphatic hydrocarbon radical or R<3> and R<4> form a ring. Certain of the above definitions are broader than those in the specification. |