摘要 |
<p>A storage stable Gefarnate-containing solid preparation in which Gefarnate is absorbed on a basic solid carrier such as magnesium silicate, metamagnesium aluminosilicate, magnesium oxide, aluminium hydroxide gel or synthetic hydrotalcite, is obtained by treating the surface of the base with a pKa adjusting agent (other than a mono- or di- saccharide or sugar alcohol) such as citric acid, sodium citrate, polyvinyl alcohol or gum arabic, to bring its surface pKa to 9.3 or less (e.g. 3-8), and then absorbing the Gefarnate onto the treated carrier.</p> |