| 摘要 |
<p>The compounds <CHEM> in which Alk is a lower alkyl group and Z is hydrogen or an amino-protecting group: <CHEM> wherein Z is hydrogen or an amino-protecting group, T is a group convertible, by hydrolysis, into an oxy group, and Q is a leaving group which, on reaction with hydroxylamine, forms a hydroxamic acid group; <CHEM> wherein Z and T are as defined above, are novel intermediates or preparing compound I. <CHEM> in which R sec is hydrogen, acetyl or a group of the general formula VII R5 - O - @ - vii in which R5 is C1-8 alkyl; phenyl; phenyl substituted in the 4-position with halogen, C1-4 alkoxy, or C1-4 alkyl; or phenylalkyl in which the phenyl group may be substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; and salts thereof. The compound I, in which R sec is hydrogen, possesses GABA-related activity.</p> |
