6,7:Seco:ergoline derivs. - having alpha adrenergic blocking, hypotensive, CNS stimulant or depressant and dopaminergic activity

摘要

of formula (I) and their salts are new. (where R1= H or CH3, R2 = 1-4C alkyl, benzyl, or phenethyl, R3 = cyano, COR5, CONHR6 or CONR7R8, R5 = OH, 1-4C alkyl, phenyl, alkoxy or amino, R6 = 1-4C alkyl, phenyl, opt. substd. pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, thiazolyl or a gp. Z = 1-3C alkyl, W = 1-4C alkyl, or benzyl, R7 and R8 = lower alkyl or together form a heterocyclic ring, R4 = H, OH or methoxy or R3 and R4 together form a gamma-lactone) (I) used as alpha-adrenergic blockers, hypotensives, CNS, stimulants and/or depressants and they have dopaminergic activity.