| 摘要 |
<p>NEW MATERIAL:Antibiotic cleomycin expressed by the formula (R is the terminal amino group of cleomycin), and a nontoxic salt thereof. EXAMPLE:3-[(S)-1'-Phenylethylamino]propylaminocleomycin. USE:An antitumor, an antimicrobial and a chemotherapeutic agent against cancer and microbism. PROCESS:A strain collection No.MK68-144 (FERM-P No.4108) of Streptomyces verticillus is incubated in a culture medium containing a nutrient source, and if necessary an aliphatic primary amine of the formula X-R11-NH2 (R11 is alkylene etc.; X is basic group) having two or more basic groups in the molecule, preferably at 20-40 deg.C and neutral pH, by the submerged spinner culture method for 2-10 days, and then the cleomycin is purified and isolated.</p> |
