21-Sulpho-propionate ester derivs. of corticoid steroid(s) - easily soluble in water, giving stable, heat sterilisable solns.

摘要

Corticoid-21-sulphopropionate derivs. of formula (I) and their salts with pharmaceutically-acceptable bases are new: (St = steroid residue of an antiinflammatory corticoid; esp. it has formula (X = H, Cl, F or CH3; Y = H, F or Cl; Z = oxo or (alpha-H, beta-OH) U-V is CH2CH2, CH=CH or R1 = H, OH or 1-8C acyloxy; R2 = H or CH3; R3 and R4 = 1-4C alkyl; and underscored ...... is a single or double bond). (I) are readily soluble in water giving conc. solns. which can be sterilized by heating and stored, and are converted rapidly to the free corticoid following injection.