| 摘要 |
Thiazole derivatives of general formula (I) <IMAGE> (I) in which n is 1 or 2 and Ar represents a phenyl radical unsubstituted or substituted by one or more substituents selected from halogen atoms, the radical CF3, the phenyl radical straight or branched chain alkyl radicals having 1 to 4 carbon atoms, and cycloalkyl radicals having 3 to 6 carbon atoms, and their pharmaceutically acceptable acid addition salts are useful in therapy as anti-depressive agents. They are prepared by reacting the thiazole <IMAGE> with a ketone X-CH2-CO-CH2O-Ar (III) (X is a leaving group, such as halogen). |
