| 摘要 |
Title penicillins (I, R = Ph, 2- or 3-thienyl; R1 = alkyl, cycloalkyl, alkenyl, alkinyl, aryl, aralkyl, heterocyclic, in vivo hydrolyzable ester group; R2 = H, salting ion, invivo hydrolyzable group), useful as bactericides, were prepd. by reaction of compd. II(R3 = lower alkyl, benzyl) and MeOH. Thus, benzyl 6-α-methyl thio-6-β-(D,L-2-phenoxy carbonyl-2-phenylacetamido) penicillanate was prepd. from benzyl-β-amido-6-α-methylthiopenicillanate toluene-4-sulfonate. The antibacterial activities of I were assessed against a variety of organisms.
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