2-Hydroxy-4-amino-6-methyl-isophthalic acid - and 2,6-di:acetyl-3-hydroxy-5-methylphenol derivs. with cardiovascular activity

摘要

New 2-hydroxy-4-methylbenzene derivs. are cpds. of formula (I) and their acid addn. salts. In (I):- each R1 (identical) is CH3 or 1-4C alkoxy; R3 and R3 are 1-4C alkyl or NR2R3 is pyrrolidino, piperidino, 4-cyano-4-methyl-1,4-diazepino, morpholino, di(1-4C alkyl) morpholino, 1,2,3,4-tetrahydro-isoquinolino, or 4-R6-piperazin-1-yl in which R6 is 1-4C alkyl, 2-hydroxyethyl, phenyl, (1-4C alkyl) phenyl; (1-4C alkoxy)phenyl, halophenyl or trifluoromethylphenyl; and R4 is H, CH3 or C2H5. (I) ahve cardiovascular activity. They are also useful as intermediates for 3-(2-pyrazolyl)-4-amino-2-hydroxyacetophenone derivs. with cardiovascular activity.