| 摘要 |
Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3 beta -yloxy) hexyl 1-thio- beta -L-fucopyranoside; 6-(5-cholesten-3 beta -yloxy) hexyl 1-thio- beta -D-galactopyranoside; 6-(5-cholesten-3 beta -yloxy)hexyl 1-thio- alpha -D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio- beta -D-galactopyranoside; 6-(5-cholesten-3 beta -yloxy)hexyl 6-amino-6-deoxy-1-thio- beta -D-galactopyranoside; or 6-(5-cholesten-3 beta -yloxy)hexyl 6-amino-6-deoxy-1-thio- alpha -D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host. |
