发明名称 Process and intermediates for preparing 11-(alkoxy- and alkylmercapto-3-oxoalkyl)-2,6-methano-3-benzazocines.
摘要 <p> &lt;CHEM&gt; where R1 is hydrogen, lower-alkyl, cyclo-alkyl-lower-alkyl, phenyl-lower-alkyl, lower-alkenyl or lower-alkynyl; three of R2, R2 min , R2 sec and R2''' are hydrogen and the fourth is hydroxy; R3 and R4 are each hydrogen or lower-alkyl, or R3 and R4 together are divalent lower-alkylene, -(CH2)m-, where m is one of the integers 3 and 4; n is one of the integers 2-4; X is oxygen or sulfur (-O- or -S-); and Alk is lower-alkyl, which comprises heating in an acid medium, a compound having the formula: &lt;CHEM&gt; where three of R2, R2 min , R2 sec and R2''' are hydrogen and the fourth is methoxymethoxy; R1, R3, R4, n, X and Alk have the meanings given above, and Alk min is lower-alkyl.</p>
申请公布号 EP0017074(A1) 申请公布日期 1980.10.15
申请号 EP19800101416 申请日期 1980.03.18
申请人 STERLING DRUG INC. 发明人 MICHNE, WILLIAM FRANCIS;LEWIS, THOMAS RICHARD
分类号 C07D221/22;C07D221/26;(IPC1-7):07D221/26;07D221/22;07D453/06 主分类号 C07D221/22
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