| 摘要 |
Peptides having the structural formula: <IMAGE> +TR <IMAGE> and <IMAGE> +TR <IMAGE> wherein A is D-Thr, D-Val; B is D-Phe, D-Tyr; C is D-Phe, D-Tyr, O-Me-D-Tyr; wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, inhibiting growth hormone release and inhibiting glucagon release in humans and animals without materially affecting gastric secretion. They have a longer duration of action than somatostatin. |
