| 摘要 |
The invention relates to 1-arylalkylimidazoles of formula <CHEM> in which A is a straight or branched alkylene group of from 1 to 3 carbon atoms, or a straight or branched alkenylene or alkynylene group of 2 or 3 carbon atoms, n is an integer which is at least 1, and the or each R substituent, which when n is greater than 1 may be the same or different, is a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated, R may also be alkoxy of from 1 to 4 carbon atoms; (when n is at least 2) alkylenedioxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkoxy; carboaryloxy; carboarylalkyloxy; -NR<6>R<7> or -CONR<6>R<7>, in which R<6> and R<7> may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; or an acid addition salt of such a 1-arylalkylimidazole. Methods of preparing these 1-arylalkylimidazoles are disclosed. The 1-arylalkylimidazoles have pharmacological properties of use in medicine, in particular for the treatment of prophylaxis of thrombo-embolic disorders. |
