Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them.

摘要

Pyrimidone derivatives, which have histamine H2-antagonist activity, of structure
<CHEM>
in which R is hydrogen, alkyl, alkanoyl or aroyl, X is hydrogen, chlorine, bromine or alkyl; Y is sulphur or methylene, n is 2 or 3, Z is hydrogen or lower alkyl, A is alkylene or -(CH2)pW(CH2)q - where W is oxygen or sulphur and p and q are such that their sum is from 1 to 4; B is hydrogen, methyl, cycloalkyl, or an optionally substituted phenyl or heteroaryl group