PREPARING AMINOALCOHOL ESTERS OF SUBSTITUTED HYDROXYCYCLOHEXANECARBOXYLIC ACIDS

摘要

The yield of compounds having the general formula: (1) wherein R represents in the process comprising reacting a substituted hydroxycyclohexanecarboxylic acid with an aminoisopropyl chloride, is highly improved by heating the reaction mixture to 160 DEG to 240 DEG C. for at least 3 hours, and distilling under reduced pressure the resulting product. Thus the content of the undesired isomer is reduced to less than 1-1.5%.