| 摘要 |
1,149,669. ArabinofuranosyI nucleotides. UPJOHN CO. 29 April, 1966 [1 June, 1965], No. 19035/66. Heading C2C. The invention comprises arabinofuranosyl nucleotides and pharmaceutically acceptable salts of formulµ where Y is uracil-1-yl, thymin-1-yl, adenin-9-yl, 6 - mercaptopurin - 9 - yl, 5 - fluorouracil - 1- yl, 5 - chlorouracil - 1 - yl, 5 - bromouracil - 1- yl, 5 - iodouracil - 1 - yl, 5 - trifluoromethyluracil - 1 - yl, 5 - methylcytosin - 1 - yl or 3- methylcytosin - 1 - yl, Y<SP>1</SP> represents the same groups as Y in which any amino or imino groups are acylated and Ac, Ac<SP>1</SP>, Ac<SP>11</SP> are acyl radicals of C 2-12 hydrocarbon monocarboxylic acids or anisoyl. They may be prepared by reacting an N<SP>4</SP> - acyl - 1 - (2<SP>1</SP>,3<SP>1</SP> - di - O - acyl- # - D - arabinofuranosyl) cytosine - 51 - phosphate with to give (VII), and hydrolysing to (VIII) if desired. Bis - (1 - # - D - arabinofuranosylcytosin - 5<SP>1</SP>-yl) phosphate is prepared similarly. Antiviral compositions comprise the compounds of Formula (VIII) and their salts. |
