| 摘要 |
NEW MATERIAL:A muramyldipeptide derivative of formula I: (X is amino acid, e.g. L-alanin, L-serine, or L-valine; n is an integer 1-6; R1 is H, lower alkyl, carboxyl group, etc.; A1 and A2 are intermediate to higher mycoloyl or 20-60C synthetic higher fatty acid residues which may be branched, one of them may be H). EXAMPLE:N<alpha>-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-N<xsi>-(6- O-mycomycoloyl- N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-L-lysine. USE:Medicines capable of preparing uniform suspensions with a phosphoric acid buffer physiological salt solution having improved lipophilic nature, and tumor cell damage activity (closely related to the antitumor activity). PROCESS:A compound of formula II is condensed with a compound of formula III by the ordinary peptide synthesis to give the objective compound of formula I. |
