发明名称 |
Process for the preparation of daunomycin |
摘要 |
<p>The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the presence of a mercury salt as catalyst and of a hydrogen chloride acceptor and then removing the trifluoroacetyl protective groups in the glycoside compounds which are formed, and separating the alpha and ss anomers. The compounds display excellent biological properties as potent inhibitors of cell mitosis and proliferative activity in cultured cells in vitro.</p> |
申请公布号 |
CH615198(A5) |
申请公布日期 |
1980.01.15 |
申请号 |
CH19750003529 |
申请日期 |
1975.03.19 |
申请人 |
SOCIETA FARMACEUTICI ITALIA SPA |
发明人 |
FEDERICO ARCAMONE;AURELIO DI MARCO;SERGIO PENCO |
分类号 |
C07H15/24;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07H15/252;(IPC1-7):07H15/24 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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