| 摘要 |
<p>The invention concerns a new process for the preparation of 5-halo-6,9 alpha -oxido-prostaglandin derivatives of the general formula II <IMAGE> (II) wherein R1 represents a hydrogen atom, an alkyl group optionally substituted by aryl, amino, hydroxyl or a halogen atom, an equivalent of a pharmaceutically acceptable organic or inorganic cation or a conventional hydroxyl protecting group; R2 represents a hydrogen atom, a hydroxyl group or a conventionally protected hydroxyl group; R3 is a hydrogen atom or a lower alkyl group; R4 represents a hydrogen atom or a conventional hydroxyl protecting group; R5 stands for a straight or branched chained alkyl group, optionally containing hetero atom(s) and optionally substituted by a substituted or unsubstituted aryl group, and X stands for a halogen atom, which comprises subsjecting prostaglandin F2 alpha derivatives of the general formula I <IMAGE> (I)</p> |
